A central online news resource for professionals involved in the development of medical publications and involved in publication planning and medical writing.
Clinical trial data is often utilised for the purposes of clinical and health policy decision-making, with journal publications and registry reports the main sources for this information. Therefore, it is … Continue Reading Insufficient harms reporting: journal publications vs clinical study reports
As a prerequisite for publication of research, the International Committee of Medical Journal Editors (ICMJE) requires registration of clinical trials and recommends this to editors of medical journals. Similarly, provision … Continue Reading Retrospective vs. prospective registration of clinical trials – what is the norm?
Clinical trials with negative results have traditionally been viewed as ‘failures’. However, in the current age of transparency, there is a strong movement to ensure that all data, positive or negative … Continue Reading Phase III cancer clinical trials: the positive side of negative results
It is established best-practice that all clinical trial outcomes should be pre-specified in a trial protocol and on a clinical trial registry and then reported once the trial is complete. … Continue Reading Fixing the problem of outcome-switching in clinical trials
Data transparency is a hot topic at the moment and there are many different views, not only on the best way to proceed, but also on the advantages and disadvantages … Continue Reading Individual patient data sharing – have we considered all angles?
Author: Jo Chapman, PhD (Aspire Scientific Ltd) Over two days last week, around 250 delegates and exhibitors braved sub-zero temperatures to attend the European meeting of the International Society for … Continue Reading Meeting report: Summary of Day 2 of the 2016 European ISMPP Meeting
The 2016 European meeting of the International Society for Medical Publication Professionals (ISMPP) has just finished. Hopefully, the tweet stream below will be helpful in providing highlights of what was presented at … Continue Reading Want to know what the highlights were from the 2016 ISMPP European Meeting? See the #ISMPP tweet stream here
Videos from the recent Cochrane Colloquium are now available (see below). Presentations (within Plenaries I and II) include: The uneven future of evidence-based medicine (Ida Sim) Can too many systematic … Continue Reading [VIDEO] Plenaries from the recent Cochrane Colloquium
In 2005, the International Committee of Medical Journal Editors (ICMJE) introduced mandatory trial registration guidelines and member journals require prospective registration of trials prior to patient enrolment as a condition … Continue Reading Evidence that industry may be better than academia at prospective trial registration, though improvements are required
A study published in BMC Medicine this week assessed the consistency between the reporting of serious adverse events (SAEs) posted at ClinicalTrials.gov and those published in corresponding journal articles. Key findings … Continue Reading Comparison of serious adverse events posted at ClinicalTrials.gov and published in corresponding journal articles
A study published in PLOS ONE in the past week investigated if the number of null results in large National Heart Lung, and Blood Institute (NHLBI) funded trials has increased … Continue Reading Likelihood of “negative” publications from large NHLBI clinical trials has increased over time
In a recent article in the Journal of Clinical Epidemiology, Ben Goldacre discusses the importance and need for improving the availability/publication of clinical trial data – particularly from the perspective … Continue Reading Fixing flaws in science must be professionalised
An Editorial has been published this week in The BMJ to mark the 10th anniversary of the landmark decision by the International Committee of Medical Journal Editors (ICMJE) to make … Continue Reading Trial registration: the single most valuable tool we have to ensure unbiased reporting of research studies
As part of the move to make clinical trial results more accessible, Elsevier is launching a new open access journal to provide an outlet for negative or less impactful trial … Continue Reading New journal will publish results from all scientifically sound clinical trials
An editorial in the BMJ this week discusses some of the harms associated with selective clinical trial reporting… specifically relating to trials of cardiovascular devices. To support the points made … Continue Reading BMJ Editorial: “Selective clinical trial reporting: betraying trial participants, harming patients”
John Hopkins University are running a free online course (via Coursera) on systematic reviews and meta-analyses. The free course will introduce methods to perform systematic reviews and meta-analysis of clinical … Continue Reading Free online course: “Introduction to Systematic Review and Meta-Analysis”